Home›Research›Compare›CJC-1295 DAC vs Sermorelin
Peptide Comparison
CJC-1295 DAC vs Sermorelin
Both are GH / IGF Axis peptides.
CJC-1295 DAC
CJC-1295 with DAC
Half-life: 6–8 days
No providers listed yet
Sermorelin
GHRH 1-29
Half-life: 10–20 minutes
443 providers listed
Bottom line
Sermorelin has published research citations on file; CJC-1295 DAC does not yet — the main evidence gap between them.
Quick Verdict
CJC-1295 DAC
Evidence
Half-life
6–8 days
Sermorelin
Evidence
Half-life
10–20 minutes
Which One Should You Choose?
| Your goal | Better option |
|---|---|
| Has published research citations | Sermorelin |
| Less frequent dosing (longer half-life) | CJC-1295 DAC |
| Lower typical price per mg | Sermorelin |
| More provider options (0 vs 443) | Sermorelin |
Research summary only — not medical advice. Consult a qualified provider before making any decisions.
Side-by-Side Comparison
Research Evidence
CJC-1295 DAC
Sermorelin
Research Citations
CJC-1295 DAC
No citations on file.
Sermorelin
About CJC-1295 DAC
CJC-1295 DAC is a GHRH analog carrying a Drug Affinity Complex (DAC) modification that binds covalently to circulating albumin, greatly extending its plasma half-life relative to unmodified or short-acting GHRH analogs. Through this albumin binding it acts as a long-lasting agonist at pituitary GHRH receptors, associated in research with sustained growth hormone and downstream IGF-1 elevation. This contrasts with the non-DAC form (Mod GRF 1-29), whose action is measured in minutes rather than days.
Research Areas
About Sermorelin
Sermorelin is a synthetic analogue of the first 29 amino acids of endogenous growth hormone-releasing hormone (GHRH). It binds to GHRH receptors on pituitary somatotrophs, stimulating pulsatile GH secretion in a physiological pattern that preserves the natural hypothalamic-pituitary feedback axis — contrasting with direct GH administration. Downstream IGF-1 elevation mediates many of its body composition, tissue-repair, and sleep quality effects.
Research Areas
Safety Profile
Information below reflects published research data only — not medical advice. Consult a qualified provider before use.
CJC-1295 DAC
Contraindications
Suggested Monitoring
Research protocols routinely measure IGF-1 to track GH axis activity before and during use. Fasting glucose and insulin are monitored because GH elevation can reduce insulin sensitivity over time.
Sermorelin
Contraindications
Suggested Monitoring
Sermorelin clinical protocols measure IGF-1 as the primary marker of GH axis response. Fasting glucose and insulin are standard baseline assessments given GH's effect on insulin sensitivity.
Used Together?
Sermorelin
Ipamorelin
Research suggests Sermorelin and Ipamorelin may produce complementary growth hormone release effects when combined. Sermorelin acts as a GHRH analogue via pituitary receptors, while Ipamorelin acts via ghrelin receptors — dual-pathway stimulation studied in GH optimization research.
Price (per mg)
CJC-1295 DAC
Sermorelin
Find Providers
Where to source these peptides
Providers offering
CJC-1295 DAC
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Providers offering
Sermorelin
443 listed
Browse directory →
PeptideBase lists providers for educational research purposes only. Always consult a qualified healthcare professional before obtaining or using any peptide.
More GH / IGF Axis Comparisons
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Cite this page
Data last updated July 3, 2026
Free to reference and republish with attribution to PeptideBase. Choose a format:
PeptideBase. (2026). CJC-1295 DAC vs Sermorelin — Per-mg Price Comparison. Retrieved July 5, 2026, from https://peptidebase.io/peptides/compare/cjc-1295-dac/sermorelin