Argireline
Price and cost-per-mg comparison
Argireline (Acetyl Hexapeptide-3) is a synthetic hexapeptide applied topically in cosmetic formulations to reduce the appearance of expression lines. It is proposed to partially inhibit the SNAP-25 component of the SNARE protein complex, attenuating the strength of muscle contractions that drive dynamic wrinkle formation. Controlled human trials have demonstrated statistically significant reductions in wrinkle depth with repeated topical application compared to placebo, representing some of the stronger human evidence available for a cosmetic peptide. Argireline is classified as a cosmetic ingredient, not a drug; it has not been evaluated by the FDA for efficacy and existing evidence is limited to cosmetic endpoints in small-to-medium trials. Argireline concentration and use: in published cosmetic studies, argireline is used at concentrations of 5–10% in topical formulations, applied to areas of dynamic expression lines such as forehead and periorbital regions. The mechanism of action — partial SNARE complex inhibition rather than complete neurotoxin-class blockade — means the effect is typically described as softening expression line depth rather than eliminating muscle movement. Results in human studies develop over 4–8 weeks of twice-daily application. Argireline vs SNAP-8: SNAP-8 (Acetyl Octapeptide-3) is a longer structural derivative of argireline developed to extend SNARE complex competitive inhibition further along the docking sequence, with manufacturer-sponsored data suggesting improved potency at lower concentrations. The key difference in evidence quality: argireline has independent peer-reviewed human trial data, while SNAP-8 data originates primarily from manufacturer-sponsored studies not indexed in standard biomedical literature. Both are topical cosmetic ingredients and neither carries regulatory drug approval. For cosmetic peptides with more systemic research profiles — including GHK-Cu, which has several decades of independent research — the PeptideBase skin and joint peptides directory covers the broader landscape.
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Filter by vial size and quantity — the figures and table follow.
| Vendor | Size | Price | Cost per mg▲ | COA | Source | Availability | Actions |
|---|---|---|---|---|---|---|---|
Other sizessingle vials, one listing each2 listingsmedian $5.00 / mg | |||||||
US ARGIRELINE PEPTIDE 10MG VIAL | 10 mg vial | $39.99 | $4.00 | — | Vendor feed · 4 wk ago | — | View ↗ |
US Argireline (5mg) | 5 mg vial | $30.00 | $6.00 | — | Vendor feed · 4 wk ago | Site offline | View ↗ |
Not comparableno resolvable mg — shown, not ranked6 listings | |||||||
US Acetyl Hexapeptide-3 (Argireline) – 200MG | mg not resolved | $202.00 | — | — | Vendor feed · 2 wk ago | In stock | View ↗ |
US Argireline | mg not resolved | $214.96 | — | — | Vendor feed · 2 wk ago | In stock | View ↗ |
US Acetyl Hexapeptide-8 (Argireline) 200MG | mg not resolved | $99.00 | — | — | Vendor feed · 2 wk ago | Out of stock | View ↗ |
US Acetyl Hexapeptide-3 (Argireline) – 200MG | mg not resolved | $226.00 | — | Vendor feed · 2 wk ago | In stock | View ↗ | |
US Acetyl Hexapeptide-8 (Raw) – 1g | mg not resolved | $129.00 | — | — | Vendor feed · 2 wk ago | In stock | View ↗ |
US Acetyl Hexapeptide-3 (Argireline) (200mg) | mg not resolved | $210.00 | — | — | Vendor feed · 2 wk ago | In stock | View ↗ |
— in COA: no certificate on file for this vendor— in availability: stock not read at the last checkPrices as scraped; foreign prices converted to USD
When Argireline prices moved
2 days in the last 120 on which a feed run read comparable Argireline prices from 3 or more vendors. Each point is the median $/mg across every comparable listing read that day, sized by how many vendors were read. A log of run days, not a continuous series.
Show as a table
| Date | Median $/mg | Vendors read |
|---|---|---|
| 26 Aug 2026 | $6.00 | 3 |
| 25 Aug 2026 | $6.00 | 3 |
How these prices are computed
The short version. The methodology page has the rest.
Source
Prices are read from each vendor's own store feed or product markup (Vendor feed). Every row says which source it came from and when it was read. Prices parsed from page text are not in this index.
$/mg
Listed price ÷ stated milligrams, converted to USD. Packs are priced on total milligrams. Listings sold per kit, per ml, as capsules or sprays, as blends, or without a stated mass are shown but not ranked.
Population
Active online research vendors only. Clinic, pharmacy and telehealth prices are excluded. Medians and the p25–p75 band are computed over comparable listings, one row per vendor product and size.
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Educational research tools — not medical advice.