Home / Combinations / Selank + Semax
CombinationCognitiveEmerging evidence
Selank + Semax
Cognitive Enhancement
A complementary nootropic stack from Russian peptide research pairing Selank's anxiolytic and stress-modulating properties with Semax's BDNF-upregulating and cognitive-enhancing effects. Selank reduces anxiety and stabilises mood via modulation of the enkephalin system and GABAergic tone, while Semax enhances focus, memory consolidation, and neuroprotection through BDNF and ACTH-related pathways. Together they aim to eliminate cognitive friction while amplifying mental output.
Stack components
SemaxCompound 01
SelankCompound 02
2
Compounds
2
Sources on file
84
Providers carry all
Mechanism
What each compound is researched for on its own. Nothing here describes an interaction between them.
Compound 01
Semax
Upregulates BDNF synthesis and mimics ACTH-derived peptide activity to enhance focus, working memory, and neuroprotection — the primary cognitive performance driver of this stack.
Compound 02
Selank
Modulates the enkephalin system and GABAergic tone to reduce anxiety and psychological stress without sedation, creating the calm mental baseline on which Semax's cognitive enhancement can operate most effectively.
Composition
2 compounds · 1 research area
Stated as recorded. This page describes each compound separately and makes no claim that they act together.
Safety notes
Both are Russian-developed synthetic peptides with a history of clinical use in Russia and Eastern Europe; neither is FDA-approved in the United States. Independent Western replication of their safety and efficacy data is limited. Both are typically administered intranasally. Potential interactions with psychiatric medications, anxiolytics, or other nootropics are not characterised; use alongside such agents warrants medical supervision.
Author-written. Not derived from any compound field, and not covered by the profile-integrity audit that gates the peptide pages.
Research references2 sources
Moderate
Semax, an Analog of ACTH(4-10) with Cognitive Effects, Regulates BDNF and tPA Expression
Ann N Y Acad Sci 2006
Weak
Effect of Selank on anxiety and depression
Eksp Klin Farmakol 2010
PeptideBase noteRussian-language journal, single institute, limited independent Western replication
no identifier on file
Related combinations2 share an area
Cognitive
Dihexa + Semax: Memory & Cognitive Performance
Dihexa+Semax
Sleep · Cognitive
DSIP + Selank: Sleep & Anxiety Relief
DSIP+Selank
1 more would appear here. Cognitive has 3 combinations in total.
Educational use only
PeptideBase documents what compounds are researched together and what evidence exists for each one separately. It does not provide medical advice, diagnosis, treatment, prescribing guidance or dosing instructions. Last reviewed 19 Apr 2026.
PeptideBase documents what compounds are researched together and what evidence exists for each one separately. It does not provide medical advice, diagnosis, treatment, prescribing guidance or dosing instructions. Last reviewed 19 Apr 2026.