Home / Combinations / DSIP + Selank
CombinationSleepCognitiveAnecdotal evidence
DSIP + Selank
Sleep & Anxiety Relief
A sleep and stress-reduction stack combining DSIP's direct sleep-promoting and sleep architecture-improving properties with Selank's daytime anxiolytic and mood-stabilising effects. DSIP is proposed to increase slow-wave delta sleep and normalise circadian sleep patterns by modulating hypothalamic sleep-wake centres, while Selank reduces anxiety, cortisol reactivity, and cognitive stress load that often prevents sleep onset. The combination targets both the quality of sleep and the psychological barriers to achieving it.
Stack components
DSIPCompound 01
SelankCompound 02
2
Compounds
2
Sources on file
47
Providers carry all
Mechanism
What each compound is researched for on its own. Nothing here describes an interaction between them.
Compound 01
DSIP
Proposed to increase slow-wave delta sleep duration and normalise disrupted sleep architecture by modulating hypothalamic sleep-wake regulatory centres — the primary sleep-inducing agent of the stack.
Compound 02
Selank
Reduces pre-sleep anxiety and cortisol reactivity through anxiolytic enkephalin modulation, addressing the psychological barrier to sleep onset that DSIP alone cannot target.
Composition
2 compounds · 2 research areas
Stated as recorded. This page describes each compound separately and makes no claim that they act together.
Safety notes
DSIP (delta sleep-inducing peptide) is a research compound; the majority of human data originates from 1970s–1980s studies with limited modern independent replication. Selank is a Russian-developed synthetic peptide not FDA-approved in the United States. Potential interactions with existing sleep medications, benzodiazepines, or anxiolytics are not characterised and warrant caution when combining. No formal safety data exists for this combination.
Author-written. Not derived from any compound field, and not covered by the profile-integrity audit that gates the peptide pages.
Research references2 sources
Weak
Delta-sleep-inducing peptide (DSIP): a review
Neurosci Biobehav Rev 1984
PeptideBase notePrimary literature is 1980s with limited modern replication
Weak
Effect of Selank on Anxiety
Eksp Klin Farmakol 2010
PeptideBase noteRussian-language journal, single institute, limited independent Western replication
no identifier on file
Related combinations3 share an area
Educational use only
PeptideBase documents what compounds are researched together and what evidence exists for each one separately. It does not provide medical advice, diagnosis, treatment, prescribing guidance or dosing instructions. Last reviewed 19 Apr 2026.
PeptideBase documents what compounds are researched together and what evidence exists for each one separately. It does not provide medical advice, diagnosis, treatment, prescribing guidance or dosing instructions. Last reviewed 19 Apr 2026.