Home›Research›Compare›Angiotensin (1-7) vs Klotho
Peptide ComparisonAngiotensin (1-7) vs Klotho
Both are Longevity & Cellular peptides.
Angiotensin (1-7)
Ang-(1-7)
Half-life: ~9–10 sec (rat)
No providers listed yet
Klotho carries stronger published evidence (Meta-analysis, 8 key studies) than Angiotensin (1-7) (RCT, 9); both are research compounds.
Angiotensin (1-7)
Half-life
~9–10 sec (rat)
Klotho
Half-life
—
| Your goal | Better option |
|---|---|
| Stronger clinical evidence | Klotho |
| Further along in FDA review | Angiotensin (1-7) |
Research summary only — not medical advice. Consult a qualified provider before making any decisions.
Angiotensin (1-7)
Klotho
Angiotensin (1-7)
Association between renin angiotensin system and cognitive outcomes over 15 years: The Look AHEAD study.
Angiotensin-(1-7) improves oxygenation in mechanically ventilated COVID-19 patients: a randomized phase 1-2 s…
Perioperative Angiotensin-(1-7) for Postoperative Cognitive Vulnerability Following Coronary Artery Bypass Su…
The Effect of Angiotensin (1-7) on Serum Metabolomics in Obese Type 2 Diabetic Mice.
+5 more
Klotho
Klotho protein and cognitive function: a systematic review and meta-analysis
Association between soluble Klotho levels and calcification propensity T50 in patients with hemodialysis: a c…
Klotho heterozygosity does not modify cognitive decline in APOE ε4 carriers: analysis of a large biobank coho…
VSIG4 Expression During Renal Aging Is Accelerated by Type 2 Diabetes in Mice.
+4 more
About Angiotensin (1-7)
Binds Mas receptor (MasR), activating nitric oxide synthase and reducing oxidative stress. Opposes TGF-β and angiotensin II signaling to reduce fibrosis. Enhances insulin sensitivity and provides cardiovascular protection.
About Klotho
Acts as a co-receptor for FGF23, regulating phosphate and vitamin D metabolism. As a circulating hormone, inhibits insulin/IGF-1 signaling to extend lifespan, activates Nrf2 antioxidant pathways, and suppresses TGF-β fibrotic signaling.
Information below reflects published research data only — not medical advice. Consult a qualified provider before use.
Angiotensin (1-7)
No established clinical contraindications. This is an investigational compound with limited human data and has not been evaluated by the FDA for safety in this context. Consult a qualified clinician.
Klotho
No established clinical contraindications. This is an investigational compound with limited human data and has not been evaluated by the FDA for safety in this context. Consult a qualified clinician.
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