Home›Research›Compare›ARA-290 vs Klotho
Peptide ComparisonARA-290 vs Klotho
Both are Longevity & Cellular peptides.
ARA-290
Cibinetide
Half-life: ~2 min (IV); ~10–20 min (SC)
17 providers listed
Klotho carries stronger published evidence (Meta-analysis, 8 key studies) than ARA-290 (RCT, 2); both are research compounds.
ARA-290
Half-life
~2 min (IV); ~10–20 min (SC)
Klotho
Half-life
—
| Your goal | Better option |
|---|---|
| Stronger clinical evidence | Klotho |
| Further along in FDA review | ARA-290 |
| More provider options (17 vs 0) | ARA-290 |
Research summary only — not medical advice. Consult a qualified provider before making any decisions.
ARA-290
Klotho
ARA-290
Klotho
Klotho protein and cognitive function: a systematic review and meta-analysis
Association between soluble Klotho levels and calcification propensity T50 in patients with hemodialysis: a c…
Klotho heterozygosity does not modify cognitive decline in APOE ε4 carriers: analysis of a large biobank coho…
VSIG4 Expression During Renal Aging Is Accelerated by Type 2 Diabetes in Mice.
+4 more
About ARA-290
Non-hematopoietic EPO analogue; activates innate repair receptor (IRR/EPOR/CD131 complex) without erythropoietic effects; promotes tissue repair and nerve healing
About Klotho
Acts as a co-receptor for FGF23, regulating phosphate and vitamin D metabolism. As a circulating hormone, inhibits insulin/IGF-1 signaling to extend lifespan, activates Nrf2 antioxidant pathways, and suppresses TGF-β fibrotic signaling.
Information below reflects published research data only — not medical advice. Consult a qualified provider before use.
ARA-290
No established clinical contraindications
Klotho
No established clinical contraindications. This is an investigational compound with limited human data and has not been evaluated by the FDA for safety in this context. Consult a qualified clinician.
ARA-290
Klotho
Not enough vendor pricing yet.
Where to source these peptides
PeptideBase lists providers for educational research purposes only. Always consult a qualified healthcare professional before obtaining or using any peptide.
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Cite this page
Data last updated August 26, 2026
Free to reference and republish with attribution to PeptideBase. Choose a format:
PeptideBase. (2026). ARA-290 vs Klotho — Per-mg Price Comparison. Retrieved September 11, 2026, from https://peptidebase.io/peptides/compare/ara-290/klotho