Home›Research›Compare›CGRP vs Larazotide
Peptide ComparisonCGRP vs Larazotide
Both are Tissue Repair peptides.
CGRP
Calcitonin Gene-Related Peptide
Half-life: ~3.6 min / ~13.6 min (biphasic; sheep)
2 providers listed
Larazotide
AT1001
Half-life: ~30 minutes (local gut action)
11 providers listed
CGRP is FDA-approved, while Larazotide is investigational — the clearest structural difference between them.
CGRP
Evidence
Half-life
~3.6 min / ~13.6 min (biphasic; sheep)
Larazotide
Evidence
Half-life
~30 minutes (local gut action)
| Your goal | Better option |
|---|---|
| Stronger clinical evidence | CGRP |
| Further along in FDA review | CGRP |
| Less frequent dosing (longer half-life) | Larazotide |
| Oral administration option | Larazotide |
| More provider options (2 vs 11) | Larazotide |
Research summary only — not medical advice. Consult a qualified provider before making any decisions.
CGRP
Larazotide
CGRP
Efficacy and tolerability of erenumab in patients with episodic migraine in whom two-to-four previous prevent…
A Controlled Trial of Erenumab for Episodic Migraine
Three-year real-world effectiveness, treatment persistence, and planned discontinuation of anti-calcitonin ge…
Astrocyte-Targeted Biomarkers for Calcitonin Gene-Related Peptide-Related Neurovascular Disorders: Insights f…
+10 more
Larazotide
Larazotide acetate for persistent symptoms of celiac disease despite a gluten-free diet: a randomized control…
Potassium-Competitive Acid Blocker Increases Ileal Permeability and Exacerbates Ileal Inflammation under Stre…
A randomized, double-blind study of larazotide acetate to prevent the activation of celiac disease during glu…
About CGRP
Binds CLR/RAMP1 receptor complex. Causes vasodilation via cAMP/PKA/nitric oxide pathway. Modulates nociceptive signaling in the trigeminal system. Promotes bone healing and has anti-inflammatory effects in peripheral tissues.
About Larazotide
Synthetic octapeptide that prevents zonulin-mediated tight junction opening; maintains intestinal epithelial barrier integrity
Information below reflects published research data only — not medical advice. Consult a qualified provider before use.
CGRP
No structured contraindication profile is available for this compound yet. This compound is FDA-approved — consult the official prescribing information or a qualified clinician.
Under clinical review
Being verified by our medical team before we display monitoring guidance for this peptide.
Larazotide
No established clinical contraindications. This is an investigational compound with limited human data and has not been evaluated by the FDA for safety in this context. Consult a qualified clinician.
Where to source these peptides
CGRP
2 listed
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Providers offeringLarazotide
11 listed
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PeptideBase lists providers for educational research purposes only. Always consult a qualified healthcare professional before obtaining or using any peptide.
More Tissue Repair Comparisons
Browse all peptides →Educational research tools — not medical advice.