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HomeResearchCompareCGRP vs LL-37

Peptide Comparison

CGRP vs LL-37

Both are Tissue Repair peptides.

CGRP

Calcitonin Gene-Related Peptide

RecoveryNot EvaluatedResearch Only

Half-life: ~3.6 min / ~13.6 min (biphasic; sheep)

2 providers listed

Full CGRP profile →
vs

LL-37

cathelicidin

RecoveryResearch Only

Half-life: ~30 minutes

40 providers listed

Full LL-37 profile →
Bottom line

CGRP carries stronger published evidence (RCT, 10 key studies) than LL-37 (Cohort study, 6); both are research compounds.

Quick Verdict

CGRP

Half-life

~3.6 min / ~13.6 min (biphasic; sheep)

LL-37

Half-life

~30 minutes

Which One Should You Choose?
Your goalBetter option
Stronger clinical evidenceCGRP
Less frequent dosing (longer half-life)LL-37
More provider options (2 vs 40)LL-37

Research summary only — not medical advice. Consult a qualified provider before making any decisions.

Side-by-Side Comparison
CGRP
LL-37
Mechanism Family
Tissue Repair
Tissue Repair
Half-life
~3.6 min / ~13.6 min (biphasic; sheep)
~30 minutes
FDA Status
not evaluated
nomination withdrawn
Admin Routes
subcutaneous, intravenous
subcutaneous, topical, intravenous
Availability
Research Only
Research Only
Providers
2 listed
40 listed
Avail. Notes
Native CGRP is not an FDA-approved drug substance; an openFDA ingredient search for "calcitonin gene-related" returns no approved product. The CGRP pathway is a validated migraine target, but via receptor ANTAGONISTS — erenumab (Aimovig, BLA 761077, approved 2018-05-17) and the gepants — not via CGRP itself. The 2018-05-17 date previously carried on this record was erenumab's approval date and has been removed.
Human cathelicidin antimicrobial peptide. Phase 1/2 trials for wound healing. No FDA approval, no NDA. Early investigational stage only. Not commercially available in US.
Research Evidence

CGRP

RCT · 10 key studies · most recent 2026

LL-37

Cohort study · 6 key studies · most recent 2026
Research Citations

About CGRP

Binds CLR/RAMP1 receptor complex. Causes vasodilation via cAMP/PKA/nitric oxide pathway. Modulates nociceptive signaling in the trigeminal system. Promotes bone healing and has anti-inflammatory effects in peripheral tissues.

Research Areas
vasodilationpain modulationwound healingbone repair

About LL-37

Human cathelicidin antimicrobial peptide; disrupts bacterial membranes and modulates innate immune response via TLR signaling

Research Areas
antimicrobialimmune modulationwound healinganti-biofilm
Safety Profile

Information below reflects published research data only — not medical advice. Consult a qualified provider before use.

CGRP

No established clinical contraindications. This is an investigational compound with limited human data and has not been evaluated by the FDA for safety in this context. Consult a qualified clinician.

Suggested Monitoring

Under clinical review

Being verified by our medical team before we display monitoring guidance for this peptide.

LL-37

Reported (Unverified — Pending Clinical Review)
sepsis risk (may be pro-inflammatory at high doses)

No established clinical contraindications

Price (per mg)

CGRP

Not enough vendor pricing yet.

LL-37

$11.80/mg

$8.16$15.20 range

28 vendors

Find Providers

Where to source these peptides

PeptideBase lists providers for educational research purposes only. Always consult a qualified healthcare professional before obtaining or using any peptide.

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Educational research tools — not medical advice.

Cite this page

Data last updated August 26, 2026

Free to reference and republish with attribution to PeptideBase. Choose a format:

PeptideBase. (2026). CGRP vs LL-37 — Per-mg Price Comparison. Retrieved September 11, 2026, from https://peptidebase.io/peptides/compare/cgrp/ll-37

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