Is CJC-1295 DAC FDA approved?

CJC-1295 DAC is not evaluated or approved by the FDA. It is discussed for research and educational purposes only, not as medical guidance.

MGF is not evaluated or approved by the FDA. It is discussed for research and educational purposes only, not as medical guidance.

How is CJC-1295 DAC administered in research settings?

In research settings, CJC-1295 DAC is typically administered via the subcutaneous route. PeptideBase does not provide dosing or administration instructions.

How is MGF administered in research settings?

In research settings, MGF is typically administered via the intramuscular route. PeptideBase does not provide dosing or administration instructions.

Home›Research›Compare›CJC-1295 DAC vs MGF

Peptide Comparison

CJC-1295 DAC vs MGF

Name: CJC-1295 DAC vs MGF — Per-mg Price Comparison
Creator: PeptideBase
License: https://peptidebase.io/terms

Both are GH / IGF Axis peptides.

CJC-1295 DAC

CJC-1295 with DAC

Fat LossNot EvaluatedResearch Only

Half-life: 6–8 days

1 providers listed

Full CJC-1295 DAC profile →

MGF

Mechano Growth Factor

PerformanceNot EvaluatedResearch Only

Half-life: Minutes (rapidly degraded; PEG-MGF for extended action)

16 providers listed

Full MGF profile →

Bottom line

CJC-1295 DAC carries stronger published evidence (RCT, 1 key studies) than MGF (Review, 6); both are research compounds.

Quick Verdict

CJC-1295 DAC

Half-life

6–8 days

MGF

Half-life

Minutes (rapidly degraded; PEG-MGF for extended action)

Which One Should You Choose?

Your goal	Better option
Stronger clinical evidence	CJC-1295 DAC
More provider options (1 vs 16)	MGF

Research summary only — not medical advice. Consult a qualified provider before making any decisions.

Side-by-Side Comparison

CJC-1295 DAC

MGF

Mechanism Family

GH / IGF Axis

Half-life

6–8 days

Minutes (rapidly degraded; PEG-MGF for extended action)

FDA Status

not evaluated

Admin Routes

subcutaneous

intramuscular

Availability

Research Only

Providers

1 listed

16 listed

Avail. Notes

Long-acting GHRH analog with a Drug Affinity Complex (DAC) modification. No FDA approval. Not on the FDA 503A bulks list. WADA-prohibited as a growth hormone releasing factor. Sold as a research chemical only.

Non-PEGylated IGF-1 splice variant (Mechano Growth Factor). No FDA approval. WADA prohibited. Not on any FDA list. Research chemical only.

Research Evidence

CJC-1295 DAC

RCT · 1 key study · dated evidence base — most recent 2006

MGF

Review · 6 key studies · most recent 2020

Research Citations

CJC-1295 DAC

RCT2006 · Journal of Clinical Endocrinology and Metabolism

Effects of a single injection of CJC-1295, a long-acting growth hormone-releasing hormone analog, in healthy…

MGF

Animal2020 · Exp Neurol

Mechano growth factor interacts with nucleolin to protect against cisplatin-induced neurotoxicity.

Animal2017 · Mol Brain

Mechano growth factor, a splice variant of IGF-1, promotes neurogenesis in the aging mouse brain.

Animal2014 · Int J Pharm

Microencapsulation of mechano growth factor E peptide for sustained delivery and bioactivity maintenance.

In vitro2011 · Mechanisms of Ageing and Development

Mechano Growth Factor E peptide (MGF-E), derived from an isoform of IGF-1, activates human muscle progenitor…

+2 more

About CJC-1295 DAC

CJC-1295 DAC is a GHRH analog carrying a Drug Affinity Complex (DAC) modification that binds covalently to circulating albumin, greatly extending its plasma half-life relative to unmodified or short-acting GHRH analogs. Through this albumin binding it acts as a long-lasting agonist at pituitary GHRH receptors, associated in research with sustained growth hormone and downstream IGF-1 elevation. This contrasts with the non-DAC form (Mod GRF 1-29), whose action is measured in minutes rather than days.

Research Areas

GH and IGF-1 elevation studied in a single-dose human PK trialsustained GHRH-receptor agonism via albumin bindingextended plasma half-life relative to short-acting GHRH analogsbody-composition and GH-axis research contextssubcutaneous administration in published research

About MGF

Splice variant of IGF-1; acts locally at site of muscle damage to activate satellite cells (muscle stem cells) for repair and hypertrophy

Research Areas

muscle satellite cell activation following mechanical loadingautocrine/paracrine local muscle repair signal (distinct from systemic IGF-1)progenitor cell proliferation and fusion enhancement in vitroPEG-MGF variant extends half-life for research applications — no human clinical data for either form

Safety Profile

Information below reflects published research data only — not medical advice. Consult a qualified provider before use.

CJC-1295 DAC

Warnings & Cautions

Active malignancy — caution (GH/IGF-1 is mitogenic)Pregnancy — cautionKnown hypersensitivityGlucose intolerance / insulin resistance

Class-based (investigational)

Suggested Monitoring

IGF-1Fasting glucoseHbA1cInsulin

Research protocols routinely measure IGF-1 to track GH axis activity before and during use. Fasting glucose and insulin are monitored because GH elevation can reduce insulin sensitivity over time.

Regulatory Notes

global — WADA

This compound falls under WADA Prohibited List category S2 (Peptide Hormones, Growth Factors, Related Substances and Mimetics), prohibited at all times for competing athletes.

source

MGF

Absolute Contraindications

Under clinical review

Being verified by our medical team before we display contraindications for this peptide.

Price (per mg)

CJC-1295 DAC

$10.63/mg

$9.74 – $15.25 range

20 vendors

View price index →Find providers →

MGF

Not enough vendor pricing yet.

Find Providers

Where to source these peptides

Providers offering

CJC-1295 DAC

1 listed

Browse directory →

Providers offering

MGF

16 listed

Browse directory →

PeptideBase lists providers for educational research purposes only. Always consult a qualified healthcare professional before obtaining or using any peptide.

More GH / IGF Axis Comparisons

Browse all peptides →

Educational research tools — not medical advice.

Cite this page

Data last updated August 26, 2026

Free to reference and republish with attribution to PeptideBase. Choose a format:

PeptideBase. (2026). CJC-1295 DAC vs MGF — Per-mg Price Comparison. Retrieved September 11, 2026, from https://peptidebase.io/peptides/compare/cjc-1295-dac/mgf

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