Cortagen vs Klotho

Vascular-targeted peptide complex that modulates endothelial cell gene expression. May support nitric oxide production, reduce vascular inflammation, and improve endothelial function.

A short peptide bioregulator derived from blood vessel tissue, developed by the Khavinson Institute. Studied for cardiovascular function support and mitigation of age-related vascular deterioration.

Acts as a co-receptor for FGF23, regulating phosphate and vitamin D metabolism. As a circulating hormone, inhibits insulin/IGF-1 signaling to extend lifespan, activates Nrf2 antioxidant pathways, and suppresses TGF-β fibrotic signaling.

A fragment of the anti-aging Klotho protein that circulates as a hormone after ectodomain shedding. Naturally declines with age. Low Klotho levels are associated with accelerated aging, cognitive decline, cardiovascular disease, and reduced lifespan in animal models.