Home›Research›Compare›Cortagen vs MOTS-c
Peptide ComparisonCortagen vs MOTS-c
Both are Longevity & Cellular peptides.
Cortagen
vascular peptide bioregulator
No providers listed yet
MOTS-c
Mitochondrial ORF of the 12S rRNA type-c
Half-life: Unknown (rapidly cleared from plasma)
181 providers listed
MOTS-c carries stronger published evidence (Cohort study, 19 key studies) than Cortagen (Review, 2); both are research compounds.
Cortagen
Evidence
MOTS-c
Evidence
| Your goal | Better option |
|---|---|
| Stronger clinical evidence | MOTS-c |
| Oral administration option | Cortagen |
| Lower typical price per mg | Cortagen |
| More provider options (0 vs 181) | MOTS-c |
Research summary only — not medical advice. Consult a qualified provider before making any decisions.
Cortagen
MOTS-c
Cortagen
MOTS-c
The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resis…
LAT1-mediated delivery of engineered R13A-MOTS-c attenuates radiation-induced lung injury via Nrf2 activation…
Circulating mitochondrial-derived microproteins at rest and in response to an acute bout of endurance exercis…
Mitochondrial-derived peptide MOTS-c activates metabolic signaling but blunts reparative function in human me…
+15 more
About Cortagen
Brain cortex-derived tetrapeptide that modulates gene expression in neural and cardiac tissue through chromatin regulatory mechanisms; microarray analysis demonstrates broad transcriptional effects following administration.
About MOTS-c
Mitochondria-derived peptide that translocates to nucleus under stress; activates AMPK pathway, regulates AICAR and folate-methionine cycle
Information below reflects published research data only — not medical advice. Consult a qualified provider before use.
Cortagen
No established clinical contraindications. This is an investigational compound with limited human data and has not been evaluated by the FDA for safety in this context. Consult a qualified clinician.
MOTS-c
No established clinical contraindications. This is an investigational compound with limited human data and has not been evaluated by the FDA for safety in this context. Consult a qualified clinician.
Cortagen
MOTS-c
Where to source these peptides
PeptideBase lists providers for educational research purposes only. Always consult a qualified healthcare professional before obtaining or using any peptide.
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Cite this page
Data last updated July 22, 2026
Free to reference and republish with attribution to PeptideBase. Choose a format:
PeptideBase. (2026). Cortagen vs MOTS-c — Per-mg Price Comparison. Retrieved July 22, 2026, from https://peptidebase.io/peptides/compare/cortagen/mots-c