Foxo4-DRI vs Klotho

D-retro-inverso peptide that disrupts Foxo4/p53 interaction in senescent cells; restores p53-mediated apoptosis selectively in senescent cells; clears cellular "zombie cells"

A breakthrough senolytic peptide that selectively eliminates senescent cells by restoring their ability to undergo apoptosis. Produced dramatic rejuvenation effects in preclinical studies.

Acts as a co-receptor for FGF23, regulating phosphate and vitamin D metabolism. As a circulating hormone, inhibits insulin/IGF-1 signaling to extend lifespan, activates Nrf2 antioxidant pathways, and suppresses TGF-β fibrotic signaling.

A fragment of the anti-aging Klotho protein that circulates as a hormone after ectodomain shedding. Naturally declines with age. Low Klotho levels are associated with accelerated aging, cognitive decline, cardiovascular disease, and reduced lifespan in animal models.