Epithalon vs Foxo4-DRI

Epithalon is believed to activate telomerase, the enzyme responsible for maintaining telomere length, with several in vitro and animal studies reporting telomere elongation. It also appears to regulate the expression of p53 and other cell-cycle control genes, modulate the hypothalamic-pituitary axis via pineal gland activity, and upregulate antioxidant defences including superoxide dismutase and catalase.

Epithalon is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) developed from research into the pineal gland peptide complex epithalamin. It is researched for its role in regulating melatonin secretion, antioxidant enzyme activity, and telomere dynamics, with a body of work primarily from Russian research groups.

D-retro-inverso peptide that disrupts Foxo4/p53 interaction in senescent cells; restores p53-mediated apoptosis selectively in senescent cells; clears cellular "zombie cells"

A breakthrough senolytic peptide that selectively eliminates senescent cells by restoring their ability to undergo apoptosis. Produced dramatic rejuvenation effects in preclinical studies.