What is the difference between AOD-9604 and MGF?

AOD-9604: AOD-9604 stimulates lipolysis and inhibits lipogenesis through mechanisms believed to be independent of the insulin-like growth factor pathway. MGF: Splice variant of IGF-1; acts locally at site of muscle damage to activate satellite cells (muscle stem cells) for repair and hypertrophy

MGF is not evaluated or approved by the FDA. It is discussed for research and educational purposes only, not as medical guidance.

How is AOD-9604 administered in research settings?

In research settings, AOD-9604 is typically administered via the subcutaneous or oral routes. PeptideBase does not provide dosing or administration instructions.

How is MGF administered in research settings?

In research settings, MGF is typically administered via the intramuscular route. PeptideBase does not provide dosing or administration instructions.

Home›Research›Compare›AOD-9604 vs MGF

Peptide Comparison

AOD-9604 vs MGF

Name: AOD-9604 vs MGF — Per-mg Price Comparison
Creator: PeptideBase
License: https://peptidebase.io/terms

Both are GH / IGF Axis peptides.

AOD-9604

Advanced Obesity Drug 9604

Fat LossResearch Only

Half-life: 30–60 minutes

195 providers listed

Full AOD-9604 profile →

MGF

Mechano Growth Factor

PerformanceNot EvaluatedResearch Only

Half-life: Minutes (rapidly degraded; PEG-MGF for extended action)

15 providers listed

Full MGF profile →

Bottom line

AOD-9604 is carried by more providers on PeptideBase (195 vs 15); otherwise the two are closely matched on the measures we track.

Quick Verdict

AOD-9604

Evidence

Preclinical

Half-life

30–60 minutes

MGF

Evidence

Preclinical

Half-life

Minutes (rapidly degraded; PEG-MGF for extended action)

Which One Should You Choose?

Your goal	Better option
Stronger clinical evidence	MGF
Oral administration option	AOD-9604
More provider options (195 vs 15)	AOD-9604

Research summary only — not medical advice. Consult a qualified provider before making any decisions.

Side-by-Side Comparison

AOD-9604

MGF

Mechanism Family

GH / IGF Axis

Half-life

30–60 minutes

Minutes (rapidly degraded; PEG-MGF for extended action)

FDA Status

nomination withdrawn

not evaluated

Admin Routes

subcutaneous, oral

intramuscular

Availability

Research Only

Providers

195 listed

15 listed

Avail. Notes

HGH fragment 176-191. Drug development terminated 2007 (Phase 3 failure). FDA GRAS notice GRN 000792 for food ingredient use only — not a drug approval. No active NDA. Research chemical.

Non-PEGylated IGF-1 splice variant (Mechano Growth Factor). No FDA approval. WADA prohibited. Not on any FDA list. Research chemical only.

Research Evidence

AOD-9604

PreclinicalAnimal · 1 key study · dated evidence base — most recent 2001

MGF

PreclinicalReview · 2 key studies · dated evidence base — most recent 2011

Research Citations

AOD-9604

Animal2001 · Endocrinology

The effect of the growth hormone fragment AOD9604 on adipose tissue

MGF

In vitro2011 · Mechanisms of Ageing and Development

Mechano Growth Factor E peptide (MGF-E), derived from an isoform of IGF-1, activates human muscle progenitor…

Review2010 · Endocrinology

Minireview: Mechano-growth factor: a putative product of IGF-I gene expression involved in tissue repair and…

About AOD-9604

AOD-9604 stimulates lipolysis and inhibits lipogenesis through mechanisms believed to be independent of the insulin-like growth factor pathway. It appears to mimic the fat-metabolising action of growth hormone without triggering the proliferative effects associated with full GH or GH-releasing peptides. Oral bioavailability has been observed in some formulations, making it of interest for non-injectable protocols.

Research Areas

selective fat tissue lipolysis via GH C-terminal fragment mechanismadipose metabolism stimulation without IGF-1 elevationoriginally developed to isolate GH lipolytic effect from growth effectssubcutaneous injection — reconstitution with bacteriostatic water required

About MGF

Splice variant of IGF-1; acts locally at site of muscle damage to activate satellite cells (muscle stem cells) for repair and hypertrophy

Research Areas

muscle satellite cell activation following mechanical loadingautocrine/paracrine local muscle repair signal (distinct from systemic IGF-1)progenitor cell proliferation and fusion enhancement in vitroPEG-MGF variant extends half-life for research applications — no human clinical data for either form

Safety Profile

Information below reflects published research data only — not medical advice. Consult a qualified provider before use.

AOD-9604

No established clinical contraindications. This is an investigational compound with limited human data and has not been evaluated by the FDA for safety in this context. Consult a qualified clinician.

MGF

Absolute Contraindications

Under clinical review

Being verified by our medical team before we display contraindications for this peptide.

Price (per mg)

AOD-9604

$9.00/mg

$7.46 – $12.15 range

61 vendors

View price index →Find providers →

MGF

Not enough vendor pricing yet.

Find Providers

Where to source these peptides

Providers offering

AOD-9604

195 listed

Browse directory →

Providers offering

MGF

15 listed

Browse directory →

PeptideBase lists providers for educational research purposes only. Always consult a qualified healthcare professional before obtaining or using any peptide.

More GH / IGF Axis Comparisons

Browse all peptides →

Educational research tools — not medical advice.

Cite this page

Data last updated July 20, 2026

Free to reference and republish with attribution to PeptideBase. Choose a format:

PeptideBase. (2026). AOD-9604 vs MGF — Per-mg Price Comparison. Retrieved July 22, 2026, from https://peptidebase.io/peptides/compare/aod-9604/mgf

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