Home›Research›Compare›CJC-1295 DAC vs MK-677
Peptide ComparisonCJC-1295 DAC vs MK-677
Both are GH / IGF Axis peptides.
CJC-1295 DAC
CJC-1295 with DAC
Half-life: 6–8 days
1 providers listed
MK-677
Ibutamoren
Half-life: 24 hours
63 providers listed
CJC-1295 DAC has a longer half-life than MK-677, so it generally needs less frequent dosing.
CJC-1295 DAC
Half-life
6–8 days
MK-677
Half-life
24 hours
| Your goal | Better option |
|---|---|
| Stronger clinical evidence | MK-677 |
| Less frequent dosing (longer half-life) | CJC-1295 DAC |
| Oral administration option | MK-677 |
| More provider options (1 vs 63) | MK-677 |
Research summary only — not medical advice. Consult a qualified provider before making any decisions.
CJC-1295 DAC
MK-677
MK-677
Oral ghrelin receptor agonist MK-0677 increases serum insulin-like growth factor 1 in hemodialysis patients:…
Two-month treatment of obese subjects with the oral growth hormone (GH) secretagogue MK-677 increases GH secr…
About CJC-1295 DAC
CJC-1295 DAC is a GHRH analog carrying a Drug Affinity Complex (DAC) modification that binds covalently to circulating albumin, greatly extending its plasma half-life relative to unmodified or short-acting GHRH analogs. Through this albumin binding it acts as a long-lasting agonist at pituitary GHRH receptors, associated in research with sustained growth hormone and downstream IGF-1 elevation. This contrasts with the non-DAC form (Mod GRF 1-29), whose action is measured in minutes rather than days.
About MK-677
MK-677 mimics the action of ghrelin by binding to and activating the GHSR-1a receptor in the pituitary gland, stimulating pulsatile GH release. Its oral bioavailability distinguishes it from peptide-based GH secretagogues and its prolonged half-life results in sustained IGF-1 elevation. Research protocols have explored its effects on lean body mass, bone mineral density, and sleep architecture.
Information below reflects published research data only — not medical advice. Consult a qualified provider before use.
CJC-1295 DAC
Class-based (investigational)
Research protocols routinely measure IGF-1 to track GH axis activity before and during use. Fasting glucose and insulin are monitored because GH elevation can reduce insulin sensitivity over time.
global — WADA
This compound falls under WADA Prohibited List category S2 (Peptide Hormones, Growth Factors, Related Substances and Mimetics), prohibited at all times for competing athletes.
sourceMK-677
Class-based (investigational)
CJC-1295 DAC
MK-677
Not enough vendor pricing yet.
Where to source these peptides
CJC-1295 DAC
1 listed
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Providers offeringMK-677
63 listed
Browse directory →
PeptideBase lists providers for educational research purposes only. Always consult a qualified healthcare professional before obtaining or using any peptide.
More GH / IGF Axis Comparisons
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Cite this page
Data last updated August 26, 2026
Free to reference and republish with attribution to PeptideBase. Choose a format:
PeptideBase. (2026). CJC-1295 DAC vs MK-677 — Per-mg Price Comparison. Retrieved September 11, 2026, from https://peptidebase.io/peptides/compare/cjc-1295-dac/mk-677