What is the difference between Cortagen and Humanin?

Cortagen: Brain cortex-derived tetrapeptide that modulates gene expression in neural and cardiac tissue through chromatin regulatory mechanisms; Humanin: Mitochondria-derived peptide; binds gp130 receptor, activates STAT3/JAK pathway; inhibits BAX-mediated apoptosis; improves insulin sensitivity

Is Cortagen FDA approved?

Cortagen is not evaluated or approved by the FDA. It is discussed for research and educational purposes only, not as medical guidance.

Is Humanin FDA approved?

Humanin is not evaluated or approved by the FDA. It is discussed for research and educational purposes only, not as medical guidance.

How is Cortagen administered in research settings?

In research settings, Cortagen is typically administered via the oral or subcutaneous routes. PeptideBase does not provide dosing or administration instructions.

How is Humanin administered in research settings?

In research settings, Humanin is typically administered via the subcutaneous or intranasal routes. PeptideBase does not provide dosing or administration instructions.

Home›Research›Compare›Cortagen vs Humanin

Peptide Comparison

Cortagen vs Humanin

Name: Cortagen vs Humanin — Per-mg Price Comparison
Creator: PeptideBase
License: https://peptidebase.io/terms

Both are Longevity & Cellular peptides.

Cortagen

vascular peptide bioregulator

LongevityNot EvaluatedResearch Only

1 providers listed

Full Cortagen profile →

Humanin

LongevityNot EvaluatedResearch Only

Half-life: ~2-4 hours

10 providers listed

Full Humanin profile →

Bottom line

Humanin is carried by more providers on PeptideBase (10 vs 1); otherwise the two are closely matched on the measures we track.

Quick Verdict

Cortagen

Half-life

—

Humanin

Half-life

~2-4 hours

Which One Should You Choose?

Your goal	Better option
Stronger clinical evidence	Humanin
Oral administration option	Cortagen
More provider options (1 vs 10)	Humanin

Research summary only — not medical advice. Consult a qualified provider before making any decisions.

Side-by-Side Comparison

Cortagen

Humanin

Mechanism Family

Longevity & Cellular

Half-life

—

~2-4 hours

FDA Status

not evaluated

Admin Routes

oral, subcutaneous

subcutaneous, intranasal

Availability

Research Only

Providers

1 listed

10 listed

Avail. Notes

—

Mitochondria-derived 21-aa cytoprotective peptide encoded in 12S rRNA. No FDA approval, no NDA or IND. Research interest in aging and neuroprotection. Research use only.

Research Evidence

Cortagen

Review · 2 key studies · most recent 2021

Humanin

Animal · 5 key studies · most recent 2026

Research Citations

Cortagen

Animal2004 · Neuroendocrinology Letters

The effect of short peptides on the expression of genes in the cardiac muscle of old male rats

Review2021 · Molecules

Peptide Regulation of Gene Expression: A Systematic Review

Humanin

Animal2026 · Biomedicines

Humanin and MOTS-c Attenuate Atrial Fibrillation by Suppressing Fibrosis and Mitochondrial Dysfunction.

Animal2026 · Toxicol Ind Health

Humanin improved the rotenone-induced reactive oxygen species formation in PC12 cells by modulating the SIRT3…

Animal2026 · Metabolites

Humanin Restores Metabolic Hormone Homeostasis of Leptin, Ghrelin, Irisin and Asprosin in Streptozotocin-Indu…

Animal2026 · Res Sq

Neuroprotective Effect of Intraperitoneal Humanin-G in Retinal Degeneration of Royal College of Surgeons Rats.

+1 more

About Cortagen

Brain cortex-derived tetrapeptide that modulates gene expression in neural and cardiac tissue through chromatin regulatory mechanisms; microarray analysis demonstrates broad transcriptional effects following administration.

Research Areas

neuroprotectiongene expression regulationlongevityanti-aging

About Humanin

Mitochondria-derived peptide; binds gp130 receptor, activates STAT3/JAK pathway; inhibits BAX-mediated apoptosis; improves insulin sensitivity

Research Areas

neuroprotectionanti-apoptoticmetabolic improvementcardiovascular protection

Safety Profile

Information below reflects published research data only — not medical advice. Consult a qualified provider before use.

Cortagen

No established clinical contraindications. This is an investigational compound with limited human data and has not been evaluated by the FDA for safety in this context. Consult a qualified clinician.

Humanin

No established clinical contraindications. This is an investigational compound with limited human data and has not been evaluated by the FDA for safety in this context. Consult a qualified clinician.

Price (per mg)

Cortagen

Not enough vendor pricing yet.

Humanin

$11.84/mg

$6.83 – $14.60 range

8 vendors

View price index →Find providers →

Find Providers

Where to source these peptides

Providers offering

Cortagen

1 listed

Browse directory →

Providers offering

Humanin

10 listed

Browse directory →

PeptideBase lists providers for educational research purposes only. Always consult a qualified healthcare professional before obtaining or using any peptide.

More Longevity & Cellular Comparisons

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Educational research tools — not medical advice.

Cite this page

Data last updated August 26, 2026

Free to reference and republish with attribution to PeptideBase. Choose a format:

PeptideBase. (2026). Cortagen vs Humanin — Per-mg Price Comparison. Retrieved September 11, 2026, from https://peptidebase.io/peptides/compare/cortagen/humanin

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