Is GLP-2 FDA approved?

GLP-2 is not evaluated or approved by the FDA. It is discussed for research and educational purposes only, not as medical guidance.

KPV is the subject of a favorable FDA advisory committee vote but not FDA approved, and its legal status for compounding is unchanged. It is discussed for research and educational purposes only, not as medical guidance.

How is GLP-2 administered in research settings?

In research settings, GLP-2 is typically administered via the subcutaneous route. PeptideBase does not provide dosing or administration instructions.

How is KPV administered in research settings?

In research settings, KPV is typically administered via the oral, subcutaneous, or topical routes. PeptideBase does not provide dosing or administration instructions.

Home›Research›Compare›GLP-2 vs KPV

Peptide Comparison

GLP-2 vs KPV

Q: What is the difference between GLP-2 and KPV?

GLP-2: Binds GLP-2 receptor on intestinal enteroendocrine cells. Promotes enterocyte proliferation and reduces apoptosis, increasing villus height and crypt depth. KPV: Derived from alpha-MSH; binds melanocortin receptors MC1R/MC3R to suppress NF-κB and inflammatory cytokines

Both are Tissue Repair peptides.

GLP-2

Glucagon-like Peptide-2

RecoveryNot EvaluatedResearch Only

11 providers listed

Full GLP-2 profile →

KPV

Lys-Pro-Val

RecoveryAdvisory Vote: FavorableResearch Only

Half-life: Short (minutes to hours)

105 providers listed

Full KPV profile →

Bottom line

GLP-2 carries stronger published evidence (RCT, 7 key studies) than KPV (Review, 3); both are research compounds.

Quick Verdict

GLP-2

KPV

Which One Should You Choose?

Your goal	Better option
Stronger clinical evidence	GLP-2
Oral administration option	KPV
More provider options (11 vs 105)	KPV

Research summary only — not medical advice. Consult a qualified provider before making any decisions.

Side-by-Side Comparison

GLP-2

KPV

Mechanism Family

Tissue Repair

Half-life

—

Short (minutes to hours)

FDA Status

not evaluated

advisory committee recommended

Admin Routes

subcutaneous

oral, subcutaneous, topical

Availability

Research Only

Providers

11 listed

105 listed

FDA Update

—

Jul 2026

Avail. Notes

Native GLP-2 is not an FDA-approved drug substance; an openFDA ingredient search for "glucagon-like" returns no approved product. The approved product is teduglutide (Gattex, NDA 203441, original approval 2012-12-21), a 33-amino-acid ANALOG of human GLP-2 — see the separate teduglutide profile. The 2012-08-30 date previously carried on this record corresponds to no locatable FDA approval action and has been removed.

Alpha-MSH C-terminal tripeptide fragment (Lys-Pro-Val). Anti-inflammatory. No FDA approval, no NDA or IND. Not on any FDA list. Research chemical only.

Research Evidence

GLP-2

RCT · 7 key studies · most recent 2026

KPV

Review · 3 key studies · most recent 2026

Research Citations

GLP-2

RCT2018 · Nutrition in Clinical Practice

Reduction of Parenteral Nutrition and Hydration Support and Safety With Long-Term Teduglutide Treatment in Pa…

Case series2026 · JPGN Rep

PERCC1-associated enteropathy: Diagnostic challenges and enteral autonomy achieved with teduglutide.

Cohort2026 · Clin Nutr

From childhood to adulthood in chronic intestinal failure: A nationwide study.

Cohort2026 · Clin Nutr

Impact of intestinal resections on the secretion of gastrointestinal hormones.

+3 more

KPV

Animal2017 · Molecular Therapy

Orally Targeted Delivery of Tripeptide KPV via Hyaluronic Acid-Functionalized Nanoparticles Efficiently Allev…

Animal2008 · Gastroenterology

PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation

Review2026 · J Sports Med Phys Fitness

A new era of doping? Use of peptide and peptide-analog drugs in recreational and professional sport and bodyb…

About GLP-2

Binds GLP-2 receptor on intestinal enteroendocrine cells. Promotes enterocyte proliferation and reduces apoptosis, increasing villus height and crypt depth. Strengthens tight junctions and reduces intestinal permeability.

Research Areas

gut lining repairintestinal integritybarrier functionanti-inflammatory

About KPV

Derived from alpha-MSH; binds melanocortin receptors MC1R/MC3R to suppress NF-κB and inflammatory cytokines

Research Areas

anti-inflammatorygut healingwound healing

Safety Profile

Information below reflects published research data only — not medical advice. Consult a qualified provider before use.

GLP-2

Absolute Contraindications

Under clinical review

Being verified by our medical team before we display contraindications for this peptide.

Suggested Monitoring

Under clinical review

Being verified by our medical team before we display monitoring guidance for this peptide.

KPV

No established clinical contraindications. This is an investigational compound with limited human data and has not been evaluated by the FDA for safety in this context. Consult a qualified clinician.

Find Providers

Where to source these peptides

Providers offering

GLP-2

11 listed

Browse directory →

Providers offering

KPV

105 listed

Browse directory →

PeptideBase lists providers for educational research purposes only. Always consult a qualified healthcare professional before obtaining or using any peptide.

More Tissue Repair Comparisons

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Educational research tools — not medical advice.