What is the difference between Hexarelin and Sermorelin?

Hexarelin: Potent synthetic GHRP; strongest GH secretagogue in its class; also activates CD36 scavenger receptor for cardioprotective effects Sermorelin: Sermorelin is a synthetic analogue of the first 29 amino acids of endogenous growth hormone-releasing hormone (GHRH).

Is Hexarelin FDA approved?

Hexarelin is not evaluated or approved by the FDA. It is discussed for research and educational purposes only, not as medical guidance.

How is Hexarelin administered in research settings?

In research settings, Hexarelin is typically administered via the subcutaneous route. PeptideBase does not provide dosing or administration instructions.

How is Sermorelin administered in research settings?

In research settings, Sermorelin is typically administered via the subcutaneous route. PeptideBase does not provide dosing or administration instructions.

Home›Research›Compare›Hexarelin vs Sermorelin

Peptide Comparison

Hexarelin vs Sermorelin

Name: Hexarelin vs Sermorelin — Per-mg Price Comparison
Creator: PeptideBase
License: https://peptidebase.io/terms

Both are GH / IGF Axis peptides.

Hexarelin

Examorelin

PerformanceNot EvaluatedResearch Only

Half-life: ~30-60 minutes

31 providers listed

Full Hexarelin profile →

Sermorelin

GHRH 1-29

PerformanceUnder clinical reviewPrescription

Half-life: 10–20 minutes

473 providers listed

Full Sermorelin profile →

Bottom line

Hexarelin has a longer half-life than Sermorelin, so it generally needs less frequent dosing.

Quick Verdict

Hexarelin

Half-life

~30-60 minutes

Sermorelin

Half-life

10–20 minutes

Which One Should You Choose?

Your goal	Better option
Stronger clinical evidence	Sermorelin
Less frequent dosing (longer half-life)	Hexarelin
More provider options (31 vs 473)	Sermorelin

Research summary only — not medical advice. Consult a qualified provider before making any decisions.

Side-by-Side Comparison

Hexarelin

Sermorelin

Mechanism Family

GH / IGF Axis

Half-life

~30-60 minutes

10–20 minutes

FDA Status

not evaluated

Under clinical review

Admin Routes

subcutaneous

Availability

Research Only

Prescription

Providers

31 listed

473 listed

Avail. Notes

Potent hexapeptide GH secretagogue. No FDA approval anywhere. Not on FDA Category 1 or Category 2 list. WADA prohibited. More potent GH pulse than GHRP-6. Research use only.

Previously FDA-approved for pediatric GH deficiency (Geref); approval withdrawn 2008. Its bulk substance appears on the FDA 503B outsourcing-facility list (Category 1) but not the 503A pharmacy bulk-substances list; compounded-product availability historically rested on the former approved-drug status.

Research Evidence

Hexarelin

RCT · 1 key study · dated evidence base — most recent 2001

Sermorelin

RCT · 3 key studies · most recent 2026

Research Citations

Hexarelin

RCT2001 · Journal of Clinical Endocrinology and Metabolism

Endocrine activities of ghrelin, a natural growth hormone secretagogue (GHS), in humans: comparison and inter…

Sermorelin

RCT2000 · European Journal of Endocrinology

The GH response to low-dose bolus growth hormone-releasing hormone (GHRH(1-29)NH2) is attenuated in patients…

RCT1999 · Clinical Endocrinology

The relative roles of continuous growth hormone-releasing hormone (GHRH(1-29)NH2) and intermittent somatostat…

Review2026 · J Sports Med Phys Fitness

A new era of doping? Use of peptide and peptide-analog drugs in recreational and professional sport and bodyb…

About Hexarelin

Potent synthetic GHRP; strongest GH secretagogue in its class; also activates CD36 scavenger receptor for cardioprotective effects

Research Areas

potent GH secretion via GHS-R1a agonismcardiac tissue activity via CD36 receptor pathwaysmuscle recovery and lean mass supportreceptor desensitization with repeated use — cycling protocols studied

About Sermorelin

Sermorelin is a synthetic analogue of the first 29 amino acids of endogenous growth hormone-releasing hormone (GHRH). It binds to GHRH receptors on pituitary somatotrophs, stimulating pulsatile GH secretion in a physiological pattern that preserves the natural hypothalamic-pituitary feedback axis — contrasting with direct GH administration. Downstream IGF-1 elevation mediates many of its body composition, tissue-repair, and sleep quality effects.

Research Areas

pulsatile GH release via direct GHRH receptor agonism at the pituitaryendogenous GH axis restoration — preserves natural pulse patterns unlike exogenous GHlean mass, sleep quality, and metabolic improvements in anti-aging clinical researchsubcutaneous injection — widely available through telehealth anti-aging providers

Safety Profile

Information below reflects published research data only — not medical advice. Consult a qualified provider before use.

Hexarelin

Absolute Contraindications

Under clinical review

Being verified by our medical team before we display contraindications for this peptide.

Sermorelin

Absolute Contraindications

Under clinical review

Being verified by our medical team before we display contraindications for this peptide.

Suggested Monitoring

IGF-1Fasting glucoseHbA1cInsulin

Sermorelin clinical protocols measure IGF-1 as the primary marker of GH axis response. Fasting glucose and insulin are standard baseline assessments given GH's effect on insulin sensitivity.

Used Together?

Sermorelin

Ipamorelin
Research suggests Sermorelin and Ipamorelin may produce complementary growth hormone release effects when combined. Sermorelin acts as a GHRH analogue via pituitary receptors, while Ipamorelin acts via ghrelin receptors — dual-pathway stimulation studied in GH optimization research.

Price (per mg)

Hexarelin

$8.85/mg

$7.60 – $11.90 range

25 vendors

View price index →Find providers →

Sermorelin

$8.40/mg

$6.92 – $10.57 range

63 vendors

View price index →Find providers →

Find Providers

Where to source these peptides

Providers offering

Hexarelin

31 listed

Browse directory →

Providers offering

Sermorelin

473 listed

Browse directory →

PeptideBase lists providers for educational research purposes only. Always consult a qualified healthcare professional before obtaining or using any peptide.

More GH / IGF Axis Comparisons

Browse all peptides →

Educational research tools — not medical advice.

Cite this page

Data last updated October 26, 2026

Free to reference and republish with attribution to PeptideBase. Choose a format:

PeptideBase. (2026). Hexarelin vs Sermorelin — Per-mg Price Comparison. Retrieved October 27, 2026, from https://peptidebase.io/peptides/compare/hexarelin/sermorelin

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