What is the difference between Epithalon and Glutathione?

Epithalon: Epithalon is believed to activate telomerase, the enzyme responsible for maintaining telomere length, with several in vitro and animal studies reporting telomere elongation. Glutathione: Master endogenous antioxidant tripeptide; neutralizes ROS, regenerates vitamins C and E, supports phase II liver detoxification, maintains intracellular redox balance

Is Epithalon FDA approved?

Epithalon is the subject of a favorable FDA advisory committee vote but not FDA approved, and its legal status for compounding is unchanged. It is discussed for research and educational purposes only, not as medical guidance.

Is Glutathione FDA approved?

Glutathione is not evaluated or approved by the FDA. It is discussed for research and educational purposes only, not as medical guidance.

How is Epithalon administered in research settings?

In research settings, Epithalon is typically administered via the subcutaneous or intravenous routes. PeptideBase does not provide dosing or administration instructions.

How is Glutathione administered in research settings?

In research settings, Glutathione is typically administered via the intravenous, subcutaneous, oral (liposomal), nebulized, or oral routes. PeptideBase does not provide dosing or administration instructions.

Home›Research›Compare›Epithalon vs Glutathione

Peptide Comparison

Epithalon vs Glutathione

Name: Epithalon vs Glutathione — Per-mg Price Comparison
Creator: PeptideBase
License: https://peptidebase.io/terms

Both are Longevity & Cellular peptides.

Epithalon

Epitalon

LongevityAdvisory Vote: FavorableResearch Only

Half-life: 30–60 minutes

176 providers listed

Full Epithalon profile →

Glutathione

gamma-glutamylcysteinylglycine

RecoveryNot EvaluatedCompoundable

Half-life: Variable (~2-5 minutes IV; hours liposomal)

136 providers listed

Full Glutathione profile →

Bottom line

Glutathione has published research citations on file; Epithalon does not yet — the main evidence gap between them.

Quick Verdict

Epithalon

Half-life

30–60 minutes

Glutathione

Half-life

Variable (~2-5 minutes IV; hours liposomal)

Which One Should You Choose?

Your goal	Better option
Has published research citations	Glutathione
Less frequent dosing (longer half-life)	Epithalon
Oral administration option	Glutathione
Lower typical price per mg	Glutathione
More provider options (176 vs 136)	Epithalon

Research summary only — not medical advice. Consult a qualified provider before making any decisions.

Side-by-Side Comparison

Epithalon

Glutathione

Mechanism Family

Longevity & Cellular

Half-life

30–60 minutes

Variable (~2-5 minutes IV; hours liposomal)

FDA Status

advisory committee recommended

not evaluated

Admin Routes

subcutaneous, intravenous

intravenous, subcutaneous, oral (liposomal), nebulized, oral

Availability

Research Only

Compoundable

Providers

176 listed

136 listed

FDA Update

Jul 2026

—

Avail. Notes

Synthetic tetrapeptide (Ala-Glu-Asp-Gly) from Khavinson Institute, Russia. Telomerase activator in research. No FDA approval, no NDA or IND. Not on any FDA list. Research chemical.

On FDA 503A Category 1 bulk drug substances list for injectable/IV compounding. Also sold as dietary supplement. Not FDA-approved as standalone drug. Compoundable by licensed 503A pharmacies.

Research Evidence

Epithalon

No citations on file

Glutathione

RCT · 1 key study · dated evidence base — most recent 2009

Research Citations

Epithalon

No citations on file.

Glutathione

RCT2009 · Movement Disorders

Randomized, double-blind, pilot evaluation of intravenous glutathione in Parkinson's disease

About Epithalon

Epithalon is believed to activate telomerase, the enzyme responsible for maintaining telomere length, with several in vitro and animal studies reporting telomere elongation. It also appears to regulate the expression of p53 and other cell-cycle control genes, modulate the hypothalamic-pituitary axis via pineal gland activity, and upregulate antioxidant defences including superoxide dismutase and catalase.

Research Areas

telomerase activation and telomere elongation in cell researchmelatonin pathway regulation via pineal gland bioregulator mechanismantioxidant and anti-aging effects (Khavinson-class tetrapeptide)subcutaneous dosing — 10–20 injection courses studied in longevity research

About Glutathione

Master endogenous antioxidant tripeptide; neutralizes ROS, regenerates vitamins C and E, supports phase II liver detoxification, maintains intracellular redox balance

Research Areas

intracellular redox homeostasis and ROS scavengingIV administration bypasses oral bioavailability failure — acute plasma GSH elevationmelanin synthesis modulation studied for skin pigmentation (mixed evidence)glutathione peroxidase substrate — core detoxification pathway cofactor

Safety Profile

Information below reflects published research data only — not medical advice. Consult a qualified provider before use.

Epithalon

No established clinical contraindications. This is an investigational compound with limited human data and has not been evaluated by the FDA for safety in this context. Consult a qualified clinician.

Glutathione

Reported (Unverified — Pending Clinical Review)

asthma (nebulized form)

No established clinical contraindications

Used Together?

Epithalon

GHK-Cu
Research suggests Epithalon and GHK-Cu may produce complementary longevity-associated effects when combined. Epithalon is studied for telomere maintenance and pineal function, while GHK-Cu is studied for antioxidant gene expression and tissue remodeling — different mechanisms in aging research.

Price (per mg)

Epithalon

$3.50/mg

$2.55 – $4.18 range

51 vendors

View price index →Find providers →

Glutathione

$0.04/mg

$0.03 – $0.09 range

10 vendors

View price index →Find providers →

Find Providers

Where to source these peptides

Providers offering

Epithalon

176 listed

Browse directory →

Providers offering

Glutathione

136 listed

Browse directory →

PeptideBase lists providers for educational research purposes only. Always consult a qualified healthcare professional before obtaining or using any peptide.

More Longevity & Cellular Comparisons

Browse all peptides →

Educational research tools — not medical advice.

Cite this page

Data last updated August 26, 2026

Free to reference and republish with attribution to PeptideBase. Choose a format:

PeptideBase. (2026). Epithalon vs Glutathione — Per-mg Price Comparison. Retrieved September 11, 2026, from https://peptidebase.io/peptides/compare/epithalon/glutathione

https://peptidebase.io/peptides/compare/epithalon/glutathione Methodology License Download JSON Download CSV