Home›Research›Compare›Ghrelin vs MK-677
Peptide ComparisonGhrelin vs MK-677
Both are GH / IGF Axis peptides.
Ghrelin
acyl ghrelin
Half-life: ~24 min (initial), ~146 min (terminal)
3 providers listed
MK-677
Ibutamoren
Half-life: 24 hours
64 providers listed
Ghrelin carries stronger published evidence (RCT, 9 key studies) than MK-677 (RCT, 2); both are research compounds.
Ghrelin
Evidence
Half-life
~24 min (initial), ~146 min (terminal)
MK-677
Evidence
Half-life
24 hours
| Your goal | Better option |
|---|---|
| Stronger clinical evidence | Ghrelin |
| Less frequent dosing (longer half-life) | MK-677 |
| Oral administration option | MK-677 |
| More provider options (3 vs 64) | MK-677 |
Research summary only — not medical advice. Consult a qualified provider before making any decisions.
Ghrelin
MK-677
Ghrelin
Associations of PYY, GLP-1 and LEAP2 with changes in feeding-related cognition, body weight and glucose homeo…
A Secondary, Subgroup Analysis of Alcohol Cue-Exposure Craving in Response to Pharmacological Inhibition of t…
Constant intravenous ghrelin infusion in healthy young men: clinical pharmacokinetics and metabolic effects
Metabolomic and proteomic analysis of ghrelin administration in mice infected with Echinococcus granulosus.
+5 more
MK-677
Oral ghrelin receptor agonist MK-0677 increases serum insulin-like growth factor 1 in hemodialysis patients:…
Two-month treatment of obese subjects with the oral growth hormone (GH) secretagogue MK-677 increases GH secr…
About Ghrelin
Must be acylated at Ser3 (by GOAT enzyme) for GHSR-1a binding. Receptor activation in the pituitary stimulates GH release; hypothalamic action via NPY/AgRP neurons increases appetite and reduces energy expenditure.
About MK-677
MK-677 mimics the action of ghrelin by binding to and activating the GHSR-1a receptor in the pituitary gland, stimulating pulsatile GH release. Its oral bioavailability distinguishes it from peptide-based GH secretagogues and its prolonged half-life results in sustained IGF-1 elevation. Research protocols have explored its effects on lean body mass, bone mineral density, and sleep architecture.
Information below reflects published research data only — not medical advice. Consult a qualified provider before use.
Ghrelin
Under clinical review
Being verified by our medical team before we display contraindications for this peptide.
MK-677
Class-based (investigational)
Ghrelin
Not enough vendor pricing yet.
MK-677
Where to source these peptides
Ghrelin
3 listed
Browse directory →
Providers offeringMK-677
64 listed
Browse directory →
PeptideBase lists providers for educational research purposes only. Always consult a qualified healthcare professional before obtaining or using any peptide.
More GH / IGF Axis Comparisons
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Cite this page
Data last updated July 20, 2026
Free to reference and republish with attribution to PeptideBase. Choose a format:
PeptideBase. (2026). Ghrelin vs MK-677 — Per-mg Price Comparison. Retrieved July 22, 2026, from https://peptidebase.io/peptides/compare/ghrelin/mk-677