Home›Research›Compare›Ghrelin vs MK-677
Peptide ComparisonGhrelin vs MK-677
Both are GH / IGF Axis peptides.
Ghrelin
acyl ghrelin
Half-life: ~24 min (initial), ~146 min (terminal)
3 providers listed
MK-677
Ibutamoren
Half-life: 24 hours
63 providers listed
Ghrelin carries stronger published evidence (RCT, 5 key studies) than MK-677 (RCT, 2); both are research compounds.
Ghrelin
Half-life
~24 min (initial), ~146 min (terminal)
MK-677
Half-life
24 hours
| Your goal | Better option |
|---|---|
| Stronger clinical evidence | Ghrelin |
| Less frequent dosing (longer half-life) | MK-677 |
| Oral administration option | MK-677 |
| More provider options (3 vs 63) | MK-677 |
Research summary only — not medical advice. Consult a qualified provider before making any decisions.
Ghrelin
MK-677
Ghrelin
A Secondary, Subgroup Analysis of Alcohol Cue-Exposure Craving in Response to Pharmacological Inhibition of t…
Pilot clinical trial of macimorelin to assess safety and efficacy in patients with cancer cachexia
Safety, tolerability, pharmacokinetics, and pharmacodynamics of macimorelin in healthy adults: Results of a s…
Constant intravenous ghrelin infusion in healthy young men: clinical pharmacokinetics and metabolic effects
+1 more
MK-677
Oral ghrelin receptor agonist MK-0677 increases serum insulin-like growth factor 1 in hemodialysis patients:…
Two-month treatment of obese subjects with the oral growth hormone (GH) secretagogue MK-677 increases GH secr…
About Ghrelin
Must be acylated at Ser3 (by GOAT enzyme) for GHSR-1a binding. Receptor activation in the pituitary stimulates GH release; hypothalamic action via NPY/AgRP neurons increases appetite and reduces energy expenditure.
About MK-677
MK-677 mimics the action of ghrelin by binding to and activating the GHSR-1a receptor in the pituitary gland, stimulating pulsatile GH release. Its oral bioavailability distinguishes it from peptide-based GH secretagogues and its prolonged half-life results in sustained IGF-1 elevation. Research protocols have explored its effects on lean body mass, bone mineral density, and sleep architecture.
Information below reflects published research data only — not medical advice. Consult a qualified provider before use.
Ghrelin
Under clinical review
Being verified by our medical team before we display contraindications for this peptide.
MK-677
Class-based (investigational)
Where to source these peptides
Ghrelin
3 listed
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Providers offeringMK-677
63 listed
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PeptideBase lists providers for educational research purposes only. Always consult a qualified healthcare professional before obtaining or using any peptide.
More GH / IGF Axis Comparisons
Browse all peptides →Educational research tools — not medical advice.