Home›Research›Compare›GHRP-2 vs MK-677
Peptide ComparisonGHRP-2 vs MK-677
Both are GH / IGF Axis peptides.
GHRP-2
Growth Hormone Releasing Peptide 2
Half-life: 15–60 minutes
42 providers listed
MK-677
Ibutamoren
Half-life: 24 hours
63 providers listed
MK-677 carries stronger published evidence (RCT, 2 key studies) than GHRP-2 (Cohort study, 2); both are research compounds.
GHRP-2
Half-life
15–60 minutes
MK-677
Half-life
24 hours
| Your goal | Better option |
|---|---|
| Stronger clinical evidence | MK-677 |
| Less frequent dosing (longer half-life) | MK-677 |
| Oral administration option | MK-677 |
| More provider options (42 vs 63) | MK-677 |
Research summary only — not medical advice. Consult a qualified provider before making any decisions.
GHRP-2
MK-677
GHRP-2
MK-677
Oral ghrelin receptor agonist MK-0677 increases serum insulin-like growth factor 1 in hemodialysis patients:…
Two-month treatment of obese subjects with the oral growth hormone (GH) secretagogue MK-677 increases GH secr…
About GHRP-2
Synthetic hexapeptide that stimulates pulsatile growth hormone release from the anterior pituitary by acting on the ghrelin receptor (GHSR-1a). Commonly stacked with GHRH analogs such as CJC-1295 or Sermorelin to amplify GH output synergistically.
About MK-677
MK-677 mimics the action of ghrelin by binding to and activating the GHSR-1a receptor in the pituitary gland, stimulating pulsatile GH release. Its oral bioavailability distinguishes it from peptide-based GH secretagogues and its prolonged half-life results in sustained IGF-1 elevation. Research protocols have explored its effects on lean body mass, bone mineral density, and sleep architecture.
Information below reflects published research data only — not medical advice. Consult a qualified provider before use.
GHRP-2
Under clinical review
Being verified by our medical team before we display contraindications for this peptide.
GHRP-2 stimulates GH and cortisol release. Research protocols measure IGF-1 for GH axis response and baseline cortisol given the compound's adrenal stimulation. Glucose markers are standard given GH's effect on insulin sensitivity.
MK-677
Class-based (investigational)
GHRP-2
Corticosteroids
Research notes that GHRP-2 stimulates cortisol and ACTH release via the HPA axis. Combined use with corticosteroid medications may affect glucocorticoid regulation. Consult your prescriber before combining.
GHRP-2
MK-677
Not enough vendor pricing yet.
Where to source these peptides
GHRP-2
42 listed
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Providers offeringMK-677
63 listed
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PeptideBase lists providers for educational research purposes only. Always consult a qualified healthcare professional before obtaining or using any peptide.
More GH / IGF Axis Comparisons
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Cite this page
Data last updated August 26, 2026
Free to reference and republish with attribution to PeptideBase. Choose a format:
PeptideBase. (2026). GHRP-2 vs MK-677 — Per-mg Price Comparison. Retrieved September 11, 2026, from https://peptidebase.io/peptides/compare/ghrp-2/mk-677