Home›Research›Compare›IGF-2 vs Sermorelin
Peptide ComparisonIGF-2 vs Sermorelin
Both are GH / IGF Axis peptides.
IGF-2
Insulin-like Growth Factor 2
Half-life: ~10-20 minutes
No providers listed yet
Sermorelin
GHRH 1-29
Half-life: 10–20 minutes
449 providers listed
Sermorelin carries stronger published evidence (RCT, 3 key studies) than IGF-2 (Case series, 6); both are research compounds.
IGF-2
Half-life
~10-20 minutes
Sermorelin
Half-life
10–20 minutes
| Your goal | Better option |
|---|---|
| Stronger clinical evidence | Sermorelin |
| More provider options (0 vs 449) | Sermorelin |
Research summary only — not medical advice. Consult a qualified provider before making any decisions.
IGF-2
Sermorelin
IGF-2
IGF-2-mediated hypoglycemia in a patient with a phyllodes tumor of the breast: a rare presentation of non-isl…
Proteomics and ex vivo plaque culture identify the insulin-like growth factor axis as a potential regulator o…
TGF-β inhibits muscle differentiation by blocking autocrine signaling pathways initiated by IGF-II
Autocrine growth factor signaling by insulin-like growth factor-II mediates MyoD-stimulated myocyte maturation
+2 more
Sermorelin
The GH response to low-dose bolus growth hormone-releasing hormone (GHRH(1-29)NH2) is attenuated in patients…
The relative roles of continuous growth hormone-releasing hormone (GHRH(1-29)NH2) and intermittent somatostat…
A new era of doping? Use of peptide and peptide-analog drugs in recreational and professional sport and bodyb…
About IGF-2
Binds IGF-1R and insulin receptor variant A; promotes anabolic signaling in muscle and fat; activates PI3K/Akt/mTOR pathway; different receptor binding profile than IGF-1
About Sermorelin
Sermorelin is a synthetic analogue of the first 29 amino acids of endogenous growth hormone-releasing hormone (GHRH). It binds to GHRH receptors on pituitary somatotrophs, stimulating pulsatile GH secretion in a physiological pattern that preserves the natural hypothalamic-pituitary feedback axis — contrasting with direct GH administration. Downstream IGF-1 elevation mediates many of its body composition, tissue-repair, and sleep quality effects.
Information below reflects published research data only — not medical advice. Consult a qualified provider before use.
IGF-2
Under clinical review
Being verified by our medical team before we display contraindications for this peptide.
Sermorelin
Under clinical review
Being verified by our medical team before we display contraindications for this peptide.
Sermorelin clinical protocols measure IGF-1 as the primary marker of GH axis response. Fasting glucose and insulin are standard baseline assessments given GH's effect on insulin sensitivity.
Sermorelin
Ipamorelin
Research suggests Sermorelin and Ipamorelin may produce complementary growth hormone release effects when combined. Sermorelin acts as a GHRH analogue via pituitary receptors, while Ipamorelin acts via ghrelin receptors — dual-pathway stimulation studied in GH optimization research.
IGF-2
Not enough vendor pricing yet.
Sermorelin
Where to source these peptides
PeptideBase lists providers for educational research purposes only. Always consult a qualified healthcare professional before obtaining or using any peptide.
More GH / IGF Axis Comparisons
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Cite this page
Data last updated August 26, 2026
Free to reference and republish with attribution to PeptideBase. Choose a format:
PeptideBase. (2026). IGF-2 vs Sermorelin — Per-mg Price Comparison. Retrieved September 11, 2026, from https://peptidebase.io/peptides/compare/igf-2/sermorelin