Home›Research›Compare›GHRP-6 vs MK-677
Peptide ComparisonGHRP-6 vs MK-677
Both are GH / IGF Axis peptides.
GHRP-6
Growth Hormone Releasing Peptide-6
Half-life: 15-60 minutes
39 providers listed
MK-677
Ibutamoren
Half-life: 24 hours
63 providers listed
MK-677 carries stronger published evidence (RCT, 2 key studies) than GHRP-6 (Review, 1); both are research compounds.
GHRP-6
Half-life
15-60 minutes
MK-677
Half-life
24 hours
| Your goal | Better option |
|---|---|
| Stronger clinical evidence | MK-677 |
| Less frequent dosing (longer half-life) | MK-677 |
| Oral administration option | MK-677 |
| More provider options (39 vs 63) | MK-677 |
Research summary only — not medical advice. Consult a qualified provider before making any decisions.
GHRP-6
MK-677
MK-677
Oral ghrelin receptor agonist MK-0677 increases serum insulin-like growth factor 1 in hemodialysis patients:…
Two-month treatment of obese subjects with the oral growth hormone (GH) secretagogue MK-677 increases GH secr…
About GHRP-6
Ghrelin receptor agonist; stimulates pituitary GH release and increases appetite via hypothalamic ghrelin pathways
About MK-677
MK-677 mimics the action of ghrelin by binding to and activating the GHSR-1a receptor in the pituitary gland, stimulating pulsatile GH release. Its oral bioavailability distinguishes it from peptide-based GH secretagogues and its prolonged half-life results in sustained IGF-1 elevation. Research protocols have explored its effects on lean body mass, bone mineral density, and sleep architecture.
Information below reflects published research data only — not medical advice. Consult a qualified provider before use.
GHRP-6
Under clinical review
Being verified by our medical team before we display contraindications for this peptide.
GHRP-6 produces stronger cortisol and prolactin stimulation than selective GH peptides. Research protocols measure IGF-1 for GH axis response and baseline cortisol. Glucose markers are standard given GH's effect on insulin sensitivity.
MK-677
Class-based (investigational)
GHRP-6
Corticosteroids
Research notes that GHRP-6 stimulates cortisol and ACTH release via the HPA axis. Combined use with corticosteroid medications may affect glucocorticoid regulation. Consult your prescriber before combining.
GHRP-6
MK-677
Not enough vendor pricing yet.
Where to source these peptides
GHRP-6
39 listed
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Providers offeringMK-677
63 listed
Browse directory →
PeptideBase lists providers for educational research purposes only. Always consult a qualified healthcare professional before obtaining or using any peptide.
More GH / IGF Axis Comparisons
Browse all peptides →Educational research tools — not medical advice.
Cite this page
Data last updated August 26, 2026
Free to reference and republish with attribution to PeptideBase. Choose a format:
PeptideBase. (2026). GHRP-6 vs MK-677 — Per-mg Price Comparison. Retrieved September 11, 2026, from https://peptidebase.io/peptides/compare/ghrp-6/mk-677