Home›Research›Compare›Epithalon vs MOTS-c
Peptide ComparisonEpithalon vs MOTS-c
Both are Longevity & Cellular peptides.
Epithalon
Epitalon
Half-life: 30–60 minutes
176 providers listed
MOTS-c
Mitochondrial ORF of the 12S rRNA type-c
Half-life: Unknown (rapidly cleared from plasma)
185 providers listed
MOTS-c has published research citations on file; Epithalon does not yet — the main evidence gap between them.
Epithalon
Half-life
30–60 minutes
MOTS-c
Half-life
Unknown (rapidly cleared from plasma)
| Your goal | Better option |
|---|---|
| Has published research citations | MOTS-c |
| Lower typical price per mg | Epithalon |
| More provider options (176 vs 185) | MOTS-c |
Research summary only — not medical advice. Consult a qualified provider before making any decisions.
Epithalon
MOTS-c
Epithalon
No citations on file.
MOTS-c
Reduced Circulating MOTS-c Levels in Hashimoto's Thyroiditis Reflect Integrated Autoimmune and Metabolic Dysr…
Humanin and MOTS-c Attenuate Atrial Fibrillation by Suppressing Fibrosis and Mitochondrial Dysfunction.
LAT1-mediated delivery of engineered R13A-MOTS-c attenuates radiation-induced lung injury via Nrf2 activation…
MOTS-c attenuates hyperoxia-induced neonatal cardiac injury by inhibiting oxeiptosis via maintaining the KEAP…
+4 more
About Epithalon
Epithalon is believed to activate telomerase, the enzyme responsible for maintaining telomere length, with several in vitro and animal studies reporting telomere elongation. It also appears to regulate the expression of p53 and other cell-cycle control genes, modulate the hypothalamic-pituitary axis via pineal gland activity, and upregulate antioxidant defences including superoxide dismutase and catalase.
About MOTS-c
Mitochondria-derived peptide that translocates to nucleus under stress; activates AMPK pathway, regulates AICAR and folate-methionine cycle
Information below reflects published research data only — not medical advice. Consult a qualified provider before use.
Epithalon
No established clinical contraindications. This is an investigational compound with limited human data and has not been evaluated by the FDA for safety in this context. Consult a qualified clinician.
MOTS-c
No established clinical contraindications. This is an investigational compound with limited human data and has not been evaluated by the FDA for safety in this context. Consult a qualified clinician.
Epithalon
GHK-Cu
Research suggests Epithalon and GHK-Cu may produce complementary longevity-associated effects when combined. Epithalon is studied for telomere maintenance and pineal function, while GHK-Cu is studied for antioxidant gene expression and tissue remodeling — different mechanisms in aging research.
Epithalon
MOTS-c
Where to source these peptides
Epithalon
176 listed
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Providers offeringMOTS-c
185 listed
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PeptideBase lists providers for educational research purposes only. Always consult a qualified healthcare professional before obtaining or using any peptide.
More Longevity & Cellular Comparisons
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Cite this page
Data last updated August 26, 2026
Free to reference and republish with attribution to PeptideBase. Choose a format:
PeptideBase. (2026). Epithalon vs MOTS-c — Per-mg Price Comparison. Retrieved September 11, 2026, from https://peptidebase.io/peptides/compare/epithalon/mots-c